Prevalence of antibodies to swine influenza viruses in humans with occupational exposure to pigs, Thuringia, Germany, 2008-2009.
Identifieur interne : 000341 ( Main/Exploration ); précédent : 000340; suivant : 000342Prevalence of antibodies to swine influenza viruses in humans with occupational exposure to pigs, Thuringia, Germany, 2008-2009.
Auteurs : Andi Krumbholz [Allemagne] ; Jeannette Lange ; Ralf Dürrwald ; Heike Hoyer ; Stefan Bengsch ; Peter Wutzler ; Roland ZellSource :
- Journal of medical virology [ 1096-9071 ] ; 2010.
Descripteurs français
- KwdFr :
- Adulte (MeSH), Adulte d'âge moyen (MeSH), Allemagne (épidémiologie), Animaux (MeSH), Anticorps antiviraux (sang), Femelle (MeSH), Grippe humaine (immunologie), Grippe humaine (sang), Grippe humaine (épidémiologie), Humains (MeSH), Maladies des agriculteurs (immunologie), Maladies des agriculteurs (virologie), Maladies des agriculteurs (épidémiologie), Mâle (MeSH), Suidae (virologie), Tests d'inhibition de l'hémagglutination (MeSH), Tests de neutralisation (MeSH), Virus de la grippe A (immunologie), Études séroépidémiologiques (MeSH).
- MESH :
- immunologie : Grippe humaine, Maladies des agriculteurs, Virus de la grippe A.
- sang : Anticorps antiviraux, Grippe humaine.
- virologie : Maladies des agriculteurs, Suidae.
- épidémiologie : Allemagne, Grippe humaine, Maladies des agriculteurs.
- Adulte, Adulte d'âge moyen, Animaux, Femelle, Humains, Mâle, Tests d'inhibition de l'hémagglutination, Tests de neutralisation, Études séroépidémiologiques.
- Wicri :
- geographic : Allemagne.
English descriptors
- KwdEn :
- Adult (MeSH), Agricultural Workers' Diseases (epidemiology), Agricultural Workers' Diseases (immunology), Agricultural Workers' Diseases (virology), Animals (MeSH), Antibodies, Viral (blood), Female (MeSH), Germany (epidemiology), Hemagglutination Inhibition Tests (MeSH), Humans (MeSH), Influenza A virus (immunology), Influenza, Human (blood), Influenza, Human (epidemiology), Influenza, Human (immunology), Male (MeSH), Middle Aged (MeSH), Neutralization Tests (MeSH), Seroepidemiologic Studies (MeSH), Swine (virology).
- MESH :
- chemical , blood : Antibodies, Viral.
- geographic , epidemiology : Germany.
- blood : Influenza, Human.
- epidemiology : Agricultural Workers' Diseases, Influenza, Human.
- immunology : Agricultural Workers' Diseases, Influenza A virus, Influenza, Human.
- virology : Agricultural Workers' Diseases, Swine.
- Adult, Animals, Female, Hemagglutination Inhibition Tests, Humans, Male, Middle Aged, Neutralization Tests, Seroepidemiologic Studies.
Abstract
The Eurasian lineages of swine influenza viruses are different genetically from classical swine H1N1 influenza viruses and comprise avian-like H1N1 and human-like H1N2 and H3N2 subtypes. Although sporadic isolation of such viruses from human specimens has been reported, the prevalence of human infections is not known. In the present study, the seroprevalence against Eurasian swine influenza viruses was investigated. Sera were collected in Thuringia, Germany, from December 2007 to April 2009. The study group comprised 118 professionals with occupational exposure to pigs (50 pig slaughterers/meat inspectors, 46 pig farmers, 22 veterinarians caring for pig herds). The control group included 118 age- and gender-matched blood donors from Thuringia. As a result, 18 sera of the study group were identified with raised hemagglutination-inhibition titers against a panel of nine swine influenza viruses (three strains/ subtype). For 17/18 sera this finding was confirmed in the neutralization assay. For 11/18 sera the raise of titers was significant, that is, a fourfold increase of hemagglutination-inhibition titers was observed. No gender-specific bias of the high titer sera was observed. Twelve sera of the control group showed increased hemagglutination-inhibition titers against swine influenza viruses. Hemagglutination-inhibition titers of 2/12 control sera were raised fourfold but did not exhibit a significant increase of neutralization titers. All increased hemagglutination-inhibition titers of the control group may be explained by cross-reactivity with seasonal influenza virus strains, as all these sera also reacted with human strains.
DOI: 10.1002/jmv.21869
PubMed: 20648619
Affiliations:
Links toward previous steps (curation, corpus...)
Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Prevalence of antibodies to swine influenza viruses in humans with occupational exposure to pigs, Thuringia, Germany, 2008-2009.</title><author><name sortKey="Krumbholz, Andi" sort="Krumbholz, Andi" uniqKey="Krumbholz A" first="Andi" last="Krumbholz">Andi Krumbholz</name><affiliation wicri:level="1"><nlm:affiliation>Department of Virology and Antiviral Therapy, Jena University Hospital, Jena, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Virology and Antiviral Therapy, Jena University Hospital, Jena</wicri:regionArea><wicri:noRegion>Jena</wicri:noRegion><wicri:noRegion>Jena</wicri:noRegion><wicri:noRegion>Jena</wicri:noRegion></affiliation></author><author><name sortKey="Lange, Jeannette" sort="Lange, Jeannette" uniqKey="Lange J" first="Jeannette" last="Lange">Jeannette Lange</name></author><author><name sortKey="Durrwald, Ralf" sort="Durrwald, Ralf" uniqKey="Durrwald R" first="Ralf" last="Dürrwald">Ralf Dürrwald</name></author><author><name sortKey="Hoyer, Heike" sort="Hoyer, Heike" uniqKey="Hoyer H" first="Heike" last="Hoyer">Heike Hoyer</name></author><author><name sortKey="Bengsch, Stefan" sort="Bengsch, Stefan" uniqKey="Bengsch S" first="Stefan" last="Bengsch">Stefan Bengsch</name></author><author><name sortKey="Wutzler, Peter" sort="Wutzler, Peter" uniqKey="Wutzler P" first="Peter" last="Wutzler">Peter Wutzler</name></author><author><name sortKey="Zell, Roland" sort="Zell, Roland" uniqKey="Zell R" first="Roland" last="Zell">Roland Zell</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2010">2010</date><idno type="RBID">pubmed:20648619</idno><idno type="pmid">20648619</idno><idno type="doi">10.1002/jmv.21869</idno><idno type="wicri:Area/Main/Corpus">000328</idno><idno type="wicri:explorRef" wicri:stream="Main" wicri:step="Corpus" wicri:corpus="PubMed">000328</idno><idno type="wicri:Area/Main/Curation">000328</idno><idno type="wicri:explorRef" wicri:stream="Main" wicri:step="Curation">000328</idno><idno type="wicri:Area/Main/Exploration">000328</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Prevalence of antibodies to swine influenza viruses in humans with occupational exposure to pigs, Thuringia, Germany, 2008-2009.</title><author><name sortKey="Krumbholz, Andi" sort="Krumbholz, Andi" uniqKey="Krumbholz A" first="Andi" last="Krumbholz">Andi Krumbholz</name><affiliation wicri:level="1"><nlm:affiliation>Department of Virology and Antiviral Therapy, Jena University Hospital, Jena, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Virology and Antiviral Therapy, Jena University Hospital, Jena</wicri:regionArea><wicri:noRegion>Jena</wicri:noRegion><wicri:noRegion>Jena</wicri:noRegion><wicri:noRegion>Jena</wicri:noRegion></affiliation></author><author><name sortKey="Lange, Jeannette" sort="Lange, Jeannette" uniqKey="Lange J" first="Jeannette" last="Lange">Jeannette Lange</name></author><author><name sortKey="Durrwald, Ralf" sort="Durrwald, Ralf" uniqKey="Durrwald R" first="Ralf" last="Dürrwald">Ralf Dürrwald</name></author><author><name sortKey="Hoyer, Heike" sort="Hoyer, Heike" uniqKey="Hoyer H" first="Heike" last="Hoyer">Heike Hoyer</name></author><author><name sortKey="Bengsch, Stefan" sort="Bengsch, Stefan" uniqKey="Bengsch S" first="Stefan" last="Bengsch">Stefan Bengsch</name></author><author><name sortKey="Wutzler, Peter" sort="Wutzler, Peter" uniqKey="Wutzler P" first="Peter" last="Wutzler">Peter Wutzler</name></author><author><name sortKey="Zell, Roland" sort="Zell, Roland" uniqKey="Zell R" first="Roland" last="Zell">Roland Zell</name></author></analytic><series><title level="j">Journal of medical virology</title><idno type="eISSN">1096-9071</idno><imprint><date when="2010" type="published">2010</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult (MeSH)</term><term>Agricultural Workers' Diseases (epidemiology)</term><term>Agricultural Workers' Diseases (immunology)</term><term>Agricultural Workers' Diseases (virology)</term><term>Animals (MeSH)</term><term>Antibodies, Viral (blood)</term><term>Female (MeSH)</term><term>Germany (epidemiology)</term><term>Hemagglutination Inhibition Tests (MeSH)</term><term>Humans (MeSH)</term><term>Influenza A virus (immunology)</term><term>Influenza, Human (blood)</term><term>Influenza, Human (epidemiology)</term><term>Influenza, Human (immunology)</term><term>Male (MeSH)</term><term>Middle Aged (MeSH)</term><term>Neutralization Tests (MeSH)</term><term>Seroepidemiologic Studies (MeSH)</term><term>Swine (virology)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Adulte (MeSH)</term><term>Adulte d'âge moyen (MeSH)</term><term>Allemagne (épidémiologie)</term><term>Animaux (MeSH)</term><term>Anticorps antiviraux (sang)</term><term>Femelle (MeSH)</term><term>Grippe humaine (immunologie)</term><term>Grippe humaine (sang)</term><term>Grippe humaine (épidémiologie)</term><term>Humains (MeSH)</term><term>Maladies des agriculteurs (immunologie)</term><term>Maladies des agriculteurs (virologie)</term><term>Maladies des agriculteurs (épidémiologie)</term><term>Mâle (MeSH)</term><term>Suidae (virologie)</term><term>Tests d'inhibition de l'hémagglutination (MeSH)</term><term>Tests de neutralisation (MeSH)</term><term>Virus de la grippe A (immunologie)</term><term>Études séroépidémiologiques (MeSH)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="blood" xml:lang="en"><term>Antibodies, Viral</term></keywords><keywords scheme="MESH" type="geographic" qualifier="epidemiology" xml:lang="en"><term>Germany</term></keywords><keywords scheme="MESH" qualifier="blood" xml:lang="en"><term>Influenza, Human</term></keywords><keywords scheme="MESH" qualifier="epidemiology" xml:lang="en"><term>Agricultural Workers' Diseases</term><term>Influenza, Human</term></keywords><keywords scheme="MESH" qualifier="immunologie" xml:lang="fr"><term>Grippe humaine</term><term>Maladies des agriculteurs</term><term>Virus de la grippe A</term></keywords><keywords scheme="MESH" qualifier="immunology" xml:lang="en"><term>Agricultural Workers' Diseases</term><term>Influenza A virus</term><term>Influenza, Human</term></keywords><keywords scheme="MESH" qualifier="sang" xml:lang="fr"><term>Anticorps antiviraux</term><term>Grippe humaine</term></keywords><keywords scheme="MESH" qualifier="virologie" xml:lang="fr"><term>Maladies des agriculteurs</term><term>Suidae</term></keywords><keywords scheme="MESH" qualifier="virology" xml:lang="en"><term>Agricultural Workers' Diseases</term><term>Swine</term></keywords><keywords scheme="MESH" qualifier="épidémiologie" xml:lang="fr"><term>Allemagne</term><term>Grippe humaine</term><term>Maladies des agriculteurs</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adult</term><term>Animals</term><term>Female</term><term>Hemagglutination Inhibition Tests</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Neutralization Tests</term><term>Seroepidemiologic Studies</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Adulte</term><term>Adulte d'âge moyen</term><term>Animaux</term><term>Femelle</term><term>Humains</term><term>Mâle</term><term>Tests d'inhibition de l'hémagglutination</term><term>Tests de neutralisation</term><term>Études séroépidémiologiques</term></keywords><keywords scheme="Wicri" type="geographic" xml:lang="fr"><term>Allemagne</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">The Eurasian lineages of swine influenza viruses are different genetically from classical swine H1N1 influenza viruses and comprise avian-like H1N1 and human-like H1N2 and H3N2 subtypes. Although sporadic isolation of such viruses from human specimens has been reported, the prevalence of human infections is not known. In the present study, the seroprevalence against Eurasian swine influenza viruses was investigated. Sera were collected in Thuringia, Germany, from December 2007 to April 2009. The study group comprised 118 professionals with occupational exposure to pigs (50 pig slaughterers/meat inspectors, 46 pig farmers, 22 veterinarians caring for pig herds). The control group included 118 age- and gender-matched blood donors from Thuringia. As a result, 18 sera of the study group were identified with raised hemagglutination-inhibition titers against a panel of nine swine influenza viruses (three strains/ subtype). For 17/18 sera this finding was confirmed in the neutralization assay. For 11/18 sera the raise of titers was significant, that is, a fourfold increase of hemagglutination-inhibition titers was observed. No gender-specific bias of the high titer sera was observed. Twelve sera of the control group showed increased hemagglutination-inhibition titers against swine influenza viruses. Hemagglutination-inhibition titers of 2/12 control sera were raised fourfold but did not exhibit a significant increase of neutralization titers. All increased hemagglutination-inhibition titers of the control group may be explained by cross-reactivity with seasonal influenza virus strains, as all these sera also reacted with human strains.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">20648619</PMID><DateCompleted><Year>2010</Year><Month>11</Month><Day>22</Day></DateCompleted><DateRevised><Year>2010</Year><Month>07</Month><Day>21</Day></DateRevised><Article PubModel="Print"><Journal><ISSN IssnType="Electronic">1096-9071</ISSN><JournalIssue CitedMedium="Internet"><Volume>82</Volume><Issue>9</Issue><PubDate><Year>2010</Year><Month>Sep</Month></PubDate></JournalIssue><Title>Journal of medical virology</Title><ISOAbbreviation>J. Med. Virol.</ISOAbbreviation></Journal><ArticleTitle>Prevalence of antibodies to swine influenza viruses in humans with occupational exposure to pigs, Thuringia, Germany, 2008-2009.</ArticleTitle><Pagination><MedlinePgn>1617-25</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1002/jmv.21869</ELocationID><Abstract><AbstractText>The Eurasian lineages of swine influenza viruses are different genetically from classical swine H1N1 influenza viruses and comprise avian-like H1N1 and human-like H1N2 and H3N2 subtypes. Although sporadic isolation of such viruses from human specimens has been reported, the prevalence of human infections is not known. In the present study, the seroprevalence against Eurasian swine influenza viruses was investigated. Sera were collected in Thuringia, Germany, from December 2007 to April 2009. The study group comprised 118 professionals with occupational exposure to pigs (50 pig slaughterers/meat inspectors, 46 pig farmers, 22 veterinarians caring for pig herds). The control group included 118 age- and gender-matched blood donors from Thuringia. As a result, 18 sera of the study group were identified with raised hemagglutination-inhibition titers against a panel of nine swine influenza viruses (three strains/ subtype). For 17/18 sera this finding was confirmed in the neutralization assay. For 11/18 sera the raise of titers was significant, that is, a fourfold increase of hemagglutination-inhibition titers was observed. No gender-specific bias of the high titer sera was observed. Twelve sera of the control group showed increased hemagglutination-inhibition titers against swine influenza viruses. Hemagglutination-inhibition titers of 2/12 control sera were raised fourfold but did not exhibit a significant increase of neutralization titers. All increased hemagglutination-inhibition titers of the control group may be explained by cross-reactivity with seasonal influenza virus strains, as all these sera also reacted with human strains.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Krumbholz</LastName><ForeName>Andi</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Department of Virology and Antiviral Therapy, Jena University Hospital, Jena, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Lange</LastName><ForeName>Jeannette</ForeName><Initials>J</Initials></Author><Author ValidYN="Y"><LastName>Dürrwald</LastName><ForeName>Ralf</ForeName><Initials>R</Initials></Author><Author ValidYN="Y"><LastName>Hoyer</LastName><ForeName>Heike</ForeName><Initials>H</Initials></Author><Author ValidYN="Y"><LastName>Bengsch</LastName><ForeName>Stefan</ForeName><Initials>S</Initials></Author><Author ValidYN="Y"><LastName>Wutzler</LastName><ForeName>Peter</ForeName><Initials>P</Initials></Author><Author ValidYN="Y"><LastName>Zell</LastName><ForeName>Roland</ForeName><Initials>R</Initials></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType></PublicationTypeList></Article><MedlineJournalInfo><Country>United States</Country><MedlineTA>J Med Virol</MedlineTA><NlmUniqueID>7705876</NlmUniqueID><ISSNLinking>0146-6615</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D000914">Antibodies, Viral</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D000328" MajorTopicYN="N">Adult</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000382" MajorTopicYN="N">Agricultural Workers' Diseases</DescriptorName><QualifierName UI="Q000453" MajorTopicYN="Y">epidemiology</QualifierName><QualifierName UI="Q000276" MajorTopicYN="N">immunology</QualifierName><QualifierName UI="Q000821" MajorTopicYN="N">virology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D000818" MajorTopicYN="N">Animals</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000914" MajorTopicYN="N">Antibodies, Viral</DescriptorName><QualifierName UI="Q000097" MajorTopicYN="Y">blood</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D005260" MajorTopicYN="N">Female</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D005858" MajorTopicYN="N" Type="Geographic">Germany</DescriptorName><QualifierName UI="Q000453" MajorTopicYN="N">epidemiology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D006385" MajorTopicYN="N">Hemagglutination Inhibition Tests</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D009980" MajorTopicYN="N">Influenza A virus</DescriptorName><QualifierName UI="Q000276" MajorTopicYN="Y">immunology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D007251" MajorTopicYN="N">Influenza, Human</DescriptorName><QualifierName UI="Q000097" MajorTopicYN="N">blood</QualifierName><QualifierName UI="Q000453" MajorTopicYN="Y">epidemiology</QualifierName><QualifierName UI="Q000276" MajorTopicYN="N">immunology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D008297" MajorTopicYN="N">Male</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008875" MajorTopicYN="N">Middle Aged</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D009500" MajorTopicYN="N">Neutralization Tests</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D016036" MajorTopicYN="N">Seroepidemiologic Studies</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D013552" MajorTopicYN="N">Swine</DescriptorName><QualifierName UI="Q000821" MajorTopicYN="Y">virology</QualifierName></MeshHeading></MeshHeadingList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="entrez"><Year>2010</Year><Month>7</Month><Day>22</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2010</Year><Month>7</Month><Day>22</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2010</Year><Month>12</Month><Day>14</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">20648619</ArticleId><ArticleId IdType="doi">10.1002/jmv.21869</ArticleId></ArticleIdList></PubmedData></pubmed><affiliations><list><country><li>Allemagne</li></country></list><tree><noCountry><name sortKey="Bengsch, Stefan" sort="Bengsch, Stefan" uniqKey="Bengsch S" first="Stefan" last="Bengsch">Stefan Bengsch</name><name sortKey="Durrwald, Ralf" sort="Durrwald, Ralf" uniqKey="Durrwald R" first="Ralf" last="Dürrwald">Ralf Dürrwald</name><name sortKey="Hoyer, Heike" sort="Hoyer, Heike" uniqKey="Hoyer H" first="Heike" last="Hoyer">Heike Hoyer</name><name sortKey="Lange, Jeannette" sort="Lange, Jeannette" uniqKey="Lange J" first="Jeannette" last="Lange">Jeannette Lange</name><name sortKey="Wutzler, Peter" sort="Wutzler, Peter" uniqKey="Wutzler P" first="Peter" last="Wutzler">Peter Wutzler</name><name sortKey="Zell, Roland" sort="Zell, Roland" uniqKey="Zell R" first="Roland" last="Zell">Roland Zell</name></noCountry><country name="Allemagne"><noRegion><name sortKey="Krumbholz, Andi" sort="Krumbholz, Andi" uniqKey="Krumbholz A" first="Andi" last="Krumbholz">Andi Krumbholz</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Sante/explor/GrippeAllemagneV4/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000341 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 000341 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Sante
|area= GrippeAllemagneV4
|flux= Main
|étape= Exploration
|type= RBID
|clé= pubmed:20648619
|texte= Prevalence of antibodies to swine influenza viruses in humans with occupational exposure to pigs, Thuringia, Germany, 2008-2009.
}}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Main/Exploration/RBID.i -Sk "pubmed:20648619" \
| HfdSelect -Kh $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd \
| NlmPubMed2Wicri -a GrippeAllemagneV4
| This area was generated with Dilib version V0.6.35. |  |